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KMID : 1134820200490080788
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 8 p.788 ~ p.795
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Anti-Aging Effects of Antirrhinum majus L. Extract on UVB-Induced Human Skin Fibroblasts
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Jang Mi
Hwang In-Guk
Kang Hae-Ju
Hwang Byung-Soon
Kim Gi-Chang
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Abstract
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This study examined the protective effects of Antirrhinum majus L. extract (AME) against ultraviolet B (UVB)-induced skin damage in human skin fibroblasts. The cell viability of human skin fibroblasts was not altered significantly by AME at concentrations of 0∼300 μg/mL. The AME treatment inhibited matrix metalloproteinase (MMP)-1 expression and MMP-1 secretion caused by UVB irradiation. Moreover, treatment with AME increased procollagen type 1 C-peptide (PIP) production and expression significantly in human skin fibroblasts irradiated with UVB. These results indicated that AME has protective effects against UVB-irradiated skin damage in human skin fibroblasts through the resulting antioxidant systems and MMP-1 expression. In addition, AME has considerable potential as a cosmetics ingredient with an anti-aging effect.
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KEYWORD
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Antirrhinum majus L., matrix metalloproteinase, type-1 collagen, ultraviolet, anti-againg
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